GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs9876781 | 1 | rs13071337 | chr3:48438189 | TREX1 | chr3:48501186-48509043:+ | -0.27 | -10.14 | 3.92E-23 | Longevity |
| BRCA | cis | rs10935120 | 1 | rs13071551 | chr3:134310867 | ANAPC13 | chr3:134196547-134204865:- | -0.4 | -12.92 | 1.35E-35 | Height |
| BRCA | cis | rs10935120 | 1 | rs13071551 | chr3:134310867 | CEP63 | chr3:134204575-134293852:+ | -0.13 | -3.57 | 0.00038 | Height |
| BRCA | cis | rs3796352 | 1 | rs13072395 | chr3:52980573 | NT5DC2 | chr3:52558386-52569093:- | -0.17 | -3.42 | 0.000644 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs13072395 | chr3:52980573 | RFT1 | chr3:53122503-53164470:- | 0.33 | 4.53 | 6.47E-6 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs13072395 | chr3:52980573 | TMEM110 | chr3:52867139-52931547:- | 0.33 | 5 | 6.85E-7 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs2070488 | 1 | rs13072809 | chr3:38468171 | LOC100128640 | chr3:38492524-38496311:- | 0.13 | 3.49 | 0.000509 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs13072809 | chr3:38468171 | XYLB | chr3:38388251-38456467:+ | 0.2 | 5.96 | 3.41E-9 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs13074025 | chr3:38455704 | LOC100128640 | chr3:38492524-38496311:- | 0.13 | 3.5 | 0.000485 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs13074025 | chr3:38455704 | XYLB | chr3:38388251-38456467:+ | 0.21 | 6.11 | 1.37E-9 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs13074160 | chr3:38455650 | LOC100128640 | chr3:38492524-38496311:- | 0.13 | 3.5 | 0.000485 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs13074160 | chr3:38455650 | XYLB | chr3:38388251-38456467:+ | 0.21 | 6.11 | 1.37E-9 | Electrocardiographic conduction measures |
| BRCA | cis | rs4679904 | 1 | rs13074231 | chr3:160355428 | TRIM59 | chr3:160153292-160167626:- | 0.13 | 4.04 | 5.65E-5 | Primary biliary cirrhosis |
| BRCA | cis | rs13098911 | 1 | rs13075270 | chr3:46253789 | CCR5 | chr3:46411633-46417690:+ | -0.07 | -3.7 | 0.000231 | Celiac disease |
| BRCA | cis | rs9876781 | 1 | rs13076076 | chr3:48479039 | TREX1 | chr3:48501186-48509043:+ | -0.26 | -10.02 | 1.15E-22 | Longevity |